Simplify both quantities first
Treat the comparison like an inequality you are trying to settle. Subtract the common part from both sides — what remains decides it.
Use the given constraint
A line of shared information above the quantities usually pins things down. Without it you would often be at "D".
Never multiply by an unknown sign
If a variable could be positive, negative, or zero, you cannot multiply or divide the comparison by it — the order might flip. This is the single biggest source of "cannot be determined".
Plug in when stuck
If algebra is messy, test allowed values (0, 1, a negative, a fraction). Consistent result ; conflicting results